Laminin alpha: (Biological Classification > Low Complexity Regions / Repeats > RefOG009) - Laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation (PUBMED:1975589). LAMA1 and LAMA2 contain multiple EGF_LAM (Laminin-type epidermal growth factor-like) domains and multiple laminin domains (LamNT, LamB, LamI and LamG). However, C-terminal G domain (LamG) exists uniquely in all alpha chains which consists of five laminin G modules. The laminins can self-assemble, bind to other matrix macromolecules, and have unique and shared cell interactions mediated by integrins, dystroglycan, and other receptors. There are at least 14 laminin isoforms that regulate a variety of cellular functions (PUBMED:9758133), (PUBMED:7827749), (PUBMED:11054872); herein, we generated a ROG based on 2 of them (LAMA1 and LAMA2).
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