Transient receptor potential cation channel, subfamily M: (Biological Classification > Speed of Evolution > High > RefOG012) - Transient receptor potential (TRP) channels are polymodal cellular sensors involved in a wide variety of cellular processes, mainly by changing membrane voltage and increasing cellular Ca(2+). The TRP channel superfamily is classified into seven related subfamilies: TRPC, TRPM, TRPV, TRPA, TRPP, TRPML, and TRPN (PMID: 21067449). Transient receptor potential (TRP) channels of the melastatin-like family (TRPM) play critical roles in mediating cellular responses to a wide range of physiological stimuli. The TRPM subfamily is composed of eight mammalian members, three of which are highly unusual ""chanzymes"" consisting of C-terminal enzyme domains (PMID: 15728426). The total length of TRPM proteins (~1000 to 2000 amino acids) varies primarily because of diversity in the regions C-terminal to the transmembrane segments.
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