LIM domain kinase: (Biological Classification > Speed of Evolution > High > RefOG016) - The LIM kinase family consists of just two members: LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2). LIM kinases regulate the architecture of the actin cytoskeleton through several signalling pathways(PMID: 17294230). All the members of the RefOG016 share either one or 2 LIM domains, 1 PDZ domain and 1 protein kinase domain. The LIM domain, which is characterist for this class of kinases, is a tandem zinc-finger structure that functions, like the PDZ, as a protein-protein interaction module (Dawid et al, 1998).
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