Otoferlin: (Biological Classification > Speed of Evolution > High > RefOG017) - Generally, ferlins are C2 domain proteins involved in membrane fusion events, including membrane repair and synaptic exocytosis. It has been reported the existence of ferlin-like proteins throughout eukaryotic evolution, from unicellular phytoplankton and apicomplexan parasites, through to humans (Lek et al, 2010). Otoferlin encodes a cytosolic protein (of 1,230 aa) with three C2 domains and a single carboxy-terminal transmembrane domain and is a potential Ca2+ sensor of transmitter release in hair cells of the inner ear (Yasunaga et al, 1999).
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