Split hand/Split foot 1 (DSS1): (Biological Classification > Speed of Evolution > Low > RefOG018) - DSS1 (or SHFM1) is a subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis (Wang et al, 2007). It is expressed in limb bud, craniofacial primordia and skin and is linked with the split hand/split food malformation, which is characterized by the absence of digital rays and syndactyly (Crackower et al, 1996). It's essential role during development justifies why it has been conserved.
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