Fillagrin: (Technical Classification > Alignment Quality > High > RefOG021) - Filaggrins are filament-associated proteins that bind to keratin fibers in epithelial cells. Reduced expression of filaggrin is associated to asthma and other dermatic diseases (e.g.eczema) (PMID: 20674819, PMID: 19958351). The proteins are synthesised as large, insoluble, highly- phosphorylated precursors, containing multiple tandem repeats of 324 amino acids (filaggrin domains), which are not separated by a large linker. This ""messy"" architecture leads to low quality of aligment and thus to inaccurate orthology assignment.
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