Low-density lipoprotein receptors: (Biological Classification > Domain Shuffling / Evolution > RefOG038) - SORL1 (sortilin-related receptor, L(DLR class) A repeats-containing) is a mosaic protein that consists of the VPS10 (vacuolar protein sorting 10) domain and the LDLR (low density lipoprotein receptor) domain (Jacobsen L et al, 2001; Hermey G., 2009). Additionally, the encoded protein contains fibronectin type III repeats and an epidermal growth factor repeat. SORL1 mediates trans-Golgi network-to-endosome sorting (Jacobsen L et al, 2001) and is genetically associated with Alzheimer disease (Rogaeva E et al, 2007).
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