FOG- Immunoglobin and related proteins: (Biological Classification > Domain Shuffling / Evolution > RefOG039) - Hemicentin is a conserved extracellular member of the immunoglobulin superfamily with 48 tandem immunoglobulin repeats, as well as the von Willebrand A (VWA) domain is a well-studied domain involved in cell adhesion, in extracellular matrix proteins (Whittaker and Hynes, 2002). Hemicentin organizes epithelial and other cell attachments into oriented line-shaped junctions (Vogel and Hedgecock, 2001).
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