RNA helicase BRR2, DEAD-box superfamily: (Biological Classification > Domain Shuffling / Evolution > RefOG040) - Human activating signal cointegrator 1 (hASC1) was originally isolated as a transcriptional coactivator of nuclear receptors (Jung DJ et al, 2002). ASCC3 -part of ASC1- is a multi-domain protein that consists of DEXDc (DEAD-like helicases superfamily) domains, HELICc (helicase superfamily c-terminal) domains and others. The DEADx helicases are involved in unwinding nucleic acids and participate in every aspect of RNA metabolism (Cordin et al, 2006).
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