Osmosensitive K+ channel histidine kinase: (Biological Classification > Pangenomes > RefOG096) - Two-component signal transduction systems enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions [PMID: 16176121]. Two-component systems are comprised of a sensor histidine kinase (HK) and its cognate response regulator (RR) [PMID: 10966457]. The HK catalyses its own auto-phosphorylation followed by the transfer of the phosphoryl group to the receiver domain on RR; phosphorylation of the RR usually activates an attached output domain, which can then effect changes in cellular physiology, often by regulating gene expression. Some HK are bifunctional, catalysing both the phosphorylation and dephosphorylation of their cognate RR. The input stimuli can regulate either the kinase or phosphatase activity of the bifunctional HK.
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