eggNOG (evolutionary genealogy of genes: Non-supervised Orthologous Groups) is a database of orthologous groups of genes. The orthologous groups are annotated with functional description lines (derived by identifying a common denominator for the genes based on their various annotations), with functional categories (i.e derived from the original COG/KOG categories).
eggNOG's database currently counts 1.7 million orthologous groups in 3686 species, covering over 7.7 million proteins (built from 9.6 million proteins).
eggNOG v4.0: nested orthology inference across 3686 organisms
Sean Powell, Kristoffer Forslund, Damian Szklarczyk, Kalliopi Trachana, Alexander Roth, Jaime Huerta-Cepas, Toni Gabaldón, Thomas Rattei, Chris Creevey, Michael Kuhn, Lars J. Jensen, Christian von Mering and Peer Bork
Nucleic Acids Res.
Epub 2013 Dec 1; PubMed 24297252.
EMBL - European Molecular Biology Laboratory
SIB - Swiss Institute of Bioinformatics
UZH - University of Zurich
BMBF - German Ministry of Education and Research
EMBO - European Molecular Biology Organization
ProBioC - Foundation ProBioC (Heidelberg)
FP6 - EU 6th Framework Program
Trying to reproduce an earlier finding? Confused? Refer to our previous releases:
eggNOG version 1.0
eggNOG version 2.0
eggNOG version 3.0
Apart from in-house predictions and transfers, eggNOG also relies on many fine resources maintained elsewhere:
...and many others.
Their input and support are gratefully acknowledged.